Apart from IDH mutation, modulation in various signaling pathways, including ceramide signaling, phosphoinositide-3-kinase–protein kinase B/Akt (P13K/AKT/mTOR) pathway, notch pathways, growth factor signaling pathway, and many others, also play a decisive position in the progression of GBM [2,3]. This evidence concerns the gene AKT1 and glioblastoma.