constructed a bifunctional small hairpin RNA (shRNA) vector containing a Bcl‐2 silencing shRNA and TLR7‐stimulated ssRNA, and stimulation with this bifunctional vector in vitro promoted significant apoptosis in mouse gastric cancer cells and inhibited subcutaneous gastric cancer cell growth in vivo by regulating the expression of apoptosis‐related proteins and inducing the release of IFNs. The gene discussed is BCL2; the disease is gastric cancer.