Some of these techniques may lead to the activation of autophagy having an added benefit, since mutations in genes encoding regulators of the autophagy and UPS machineries, such as p62/SQSTM1, VCP or Ubiquilin-2 are often found in FTD or ALS and are thought to cause downregulation of autophagy/proteasomal functions (Deng et al., 2017). This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.