This is consistent with a study by Colleoni et al who found a statistically significant higher pCR rate in patients with estrogen and progesterone absent tumors (adjusted OR = 14.4).46 Previous studies indicated that the absence of hormone receptor expression and Ki-67 ≥ 20% were predictive of a clinical complete response.47 A high tumor grade has been reported as a predictive factor of pCR.47 However, our results did not replicate the significant effect of tumor grade in pCR. The gene discussed is MKI67; the disease is neoplasm.