However, methemoglobinemia showed no significant effect on the hypertensive effects of Na2S infusion even though the circulating methemoglobin could adequately scavenge all administered H2S. Thus, it is likely that the hypertensive effects that followed Na2S infusion were due to a metabolite of H2S rather than H2S. The predominant metabolites of H2S include HSOH, metHb‐SH− complexes, persulfide, polysulfide, and thiolsulfate. The gene discussed is HBG2; the disease is methemoglobinemia.