F2 and cancer: The International Society on Thrombosis and Haemostasis (ISTH) has established criteria, based on levels of D-dimer, fibrinogen, platelet count, and prothrombin time, to diagnose overt DIC in patients with malignancy.111 While D-dimer elevations are common in patients with cancer and stroke, overt DIC fulfilling ISTH criteria is rare.97