As a result, we identified a high overlap between DMPs and DMRs associated with MetS, which induced differential methylation enriched at genes involved in inflammatory pathways, including TNF/IFN/NF-KB/STAT (tumor necrosis factor/interferon/signal transducers and activators of transcription) signaling pathways, as identified in the hallmark supersets. The gene discussed is NFKB1; the disease is metabolic syndrome.