PANX1 and migraine with aura: For example, blockade of Panx1 activation reduced cortical susceptibility to cortical spreading depression in migraine aura pathogenesis [45]; Panx1 blockers (10Panx peptide, carbenoxolone, and Pbcd) decreased mechanical hyperalgesia by inhibiting nocioceptor ion channels [NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R)] in a spared nerve injury rat model [33].