Interestingly, when analysing this correlation across multiple cancer types (Fig. S1), we observed that decreased expression of RNF144B significantly correlated with a worsened prognosis exclusively in the LUAD patients with wild-type TP53, and not in those with mutant TP53 (Fig. 1D), supporting the role for RNF144B in LUAD, particularly when TP53 wild-type is functional. Here, TP53 is linked to cancer.