Recently, it has been described how the knock-down of several TP53-dependent proteins that have a role in DNA damage response, such as CAV1, MLH1, MSH2, DDIT4, POLK, ERCC5, FANCC or RNF144B, was enough to accelerate Eμ Myc-driven lymphoma [23, 26]. The gene discussed is TP53; the disease is lymphoma.