We selected miR-127-3p for further evaluation for several reasons: 1) Among the well-known tumor-suppressor genes that suppress Bcl-6 in many types of cancer, it is one of the most important miRNAs; 2) It has EXOmotif sequences that are may be sorted into exosome cargo; and 3) Among the genes downregulated in RAB27A-OE RCC cells (detected by miRNA sequencing), it had one of the highest fold changes (− 339.420703) (p = 2.28705E-13). The gene discussed is BCL6; the disease is cancer.