MYCN and cancer: Based on the findings of our in vitro study, we hypothesize that the metastatic potential of in RAB27A overexpressing cells, reflected by cancer cell phenotypic properties as migration, proliferation, cell adhesion, and cell differentiation, might be accelerated via MYCN-induced activation of the MAPK signaling pathway, possibly due to a decrease in post-transcriptional changes owing to exosomal secretion of the tumor suppressor gene miR-127-3p.