Another study found that blood group B was associated with an increased risk of severe malaria [OR = 1.638 (95% CI 1.128–2.380)] and after adjusting for age, gender, haematocrit, parasite density, and Hb genotype, we confirm from this large study in Nigerian children that the greater protective effect of the heterozygous sickle cell state against cerebral malaria and severe malarial anaemia) [11, 12]. This evidence concerns the gene GSTM1 and cerebral malaria.