Furthermore, a significant increase in the expression of the inflammation-inducing secreted protein lipocalin 2 (LCN2) was similarly observed in hypothalamic microglia at the cachexia stage, but not at the pre-cachexia stage (Fig. 3G, M, Unpaired t-test, **p < 0.01 vs. control group). Here, LCN2 is linked to Cachexia.