A negative correlation was observed between PD-1 or CD112R mRNA expression and LCN2 mRNA expression in hypothalamic microglia at the pre-cachexia and cachexia stage after transplantation of pancreatic cancer cells (Fig. 3N, R=-0.5326, p = 0.0337, Fig. 3O; R = -0.6704, p = 0.0045). Here, LCN2 is linked to familial pancreatic carcinoma.