Indeed, MFS shares cardiovascular and skeletal features with related conditions, notably Loeys-Dietz syndromes (LDS) that are linked to pathogenic variants of genes encoding components of the TGFβ signaling pathway, notably transforming growth factor beta-receptors 1 and 2 (TGFβR1 and TGFβR2) and mothers against decapentaplegic homolog 3 (SMAD3) [4]. The gene discussed is TGFBR1; the disease is Loeys-Dietz syndrome.