Inflammatory factors such as Tumornecrosisfactor-α( tumor necrosis factor-α (TNF-α), IL-1, and IL-6 act on the OPG/RANKL/RANK signal transduction pathway, inducing an imbalance in osteocyte autophagy and mitophagy to destroy the balance of bone turnover, which may be the key to the molecular mechanism of RA complicated with CN [10–14]. The gene discussed is TNF; the disease is rheumatoid arthritis.