In the present study, we focused on exploring the key crosstalk genes (ITGAX and COL4A2) shared by intracranial aneurysms and periodontitis as well as the transcription factor (GATA2) regulating key crosstalk genes by bioinformatics approach, which was fully validated in an external independent datasets. Here, GATA2 is linked to Dilatation of the cerebral artery.