Of note, ALS patients are subject to numerous other forms of stress in addition to that caused by energy imbalance (Masrori and Van Damme, 2020), and therefore, the potential contributions of the other three stress-sensing ISR kinases (i.e., PERK, PKR, and HRI) should also be considered. The gene discussed is EIF2AK2; the disease is amyotrophic lateral sclerosis.