This extensive evidence of ASNS upregulation in murine and in patients’ tissues, along with our previous observation of the strong effect of Asns silencing in retarding growth in Pkd1−/− MEFs provided the rationale for targeting ASNS in an orthologous mouse model of ADPKD, which mimics the slow progression of the pathology observed in patients. Here, ASNS is linked to autosomal dominant polycystic kidney disease.