CAD and autosomal dominant polycystic kidney disease: Consistently, CAD was transcriptionally upregulated in different previously published datasets of PKD animal models, namely Pkd1v/v (Fig. 6B; Podrini et al, 2018) and Pkd1RC/RC murine kidneys (Fig. 6C; Olson et al, 2019), as well as in microarrays (Fig. 6D; Song et al, 2009) and in snRNA-seq (Fig. 6E; Muto et al, 2021) datasets from ADPKD patients, the last one mainly in the proximal tubule cluster of diseased kidneys.