ASNS and autosomal dominant polycystic kidney disease: Of great interest, and in line with the model that we had proposed, a recent study found an increase in circulating asparagine in children and young adult PKD patients (Baliga et al, 2021), along with changes in the critical metabolites glutamine, glutamate and aspartate, products and substrates of the enzyme ASNS (Lomelino et al, 2017), providing strong supporting evidence of deregulation of this pathway in ADPKD patients.