F8 and hemophilia B: All these cell types are important targets for different therapeutic purposes, in particular, hepatocytes naturally produce coagulation factor IX (FIX), which is lacking in hemophilia B, while coagulation factor VIII (FVIII), whose lack causes hemophilia A, is physiologically produced by LSEC, among other sources (Follenzi et al, 2008; Zanolini et al, 2015).