C5AR1 and kidney disorder: Furthermore, the importance of C5a and its receptor (C5aR) in kidney diseases has been described in animal models of lethal C3 glomerulopathy93, ischemia-reperfusion94,95, lupus nephritis96, immunoglobulin A nephropathy97, rhabdomyolysis-induced AKI98, diabetic kidney disease99 and in human mesangial proliferative GN100.