SPTBN2 and neoplasm: When we further investigated the relationship between SPTBN2 expression and tumor stem cell score, a significant positive correlation was observed between SPTBN2 expression and both DNAss (Supplemental Fig. 2a) and EREG-METHss (Supplemental Fig. 2b) scores in most malignancies, but especially in PAAD, CESC, and STES (p < 0.05).