In addition, up-regulation of SPTBN2 in PAAD was associated with increased expression of chemokine receptors (CXCR5, CCR10), major histocompatibility complex (MHC) molecules (TAP2, TAPBP), immunosuppressive molecules (TGFB1), and immunostimulatory molecules (TNFSF13, CD40, NT5E, and CD276). The gene discussed is NT5E; the disease is pancreatic adenocarcinoma.