In the present study, by analyzing the multi-omics data, including SPTBN2 expression levels, genetic alterations, prognostic value, DNA methylation, tumor immunity, and mechanisms of action, the value of SPTBN2 in pan-cancer was comprehensively and systematically explored, in particular the role of SPTBN2 in PAAD. The gene discussed is SPTBN2; the disease is pancreatic adenocarcinoma.