CD40 and pancreatic adenocarcinoma: In addition, up-regulation of SPTBN2 in PAAD was associated with increased expression of chemokine receptors (CXCR5, CCR10), major histocompatibility complex (MHC) molecules (TAP2, TAPBP), immunosuppressive molecules (TGFB1), and immunostimulatory molecules (TNFSF13, CD40, NT5E, and CD276).