CTRB2 and familial pancreatic carcinoma: However, the CTRB1 region on chromosome 16 contains various complex genomic rearrangements that include a short deletion in CTRB2 associated with pancreas cancer risk25 and a 16.6kb inversion between CTRB1 and CTRB2, which is associated with chronic pancreatitis26, a risk factor for pancreatic cancer.