Eight proteins (TNFRSF10B, F2, CTSS, VARS1, ASIP, IRF3, MAPRE1, COMMD7) had an association with risk of non-malignant melanoma of which four (F2, VARS1, IRF3, and MAPRE1) were not observed to associate with other cancers in this study, such as IRF3 [OR: 0.53, 95% CI: 0.41 to 0.70; PP4: 0.87]. This evidence concerns the gene MAPRE1 and melanoma.