Eight proteins (A4GALT, ASIP, CTSF, MARE1, PDXK, SEM4A, PLAUR, VARS1) were observed to have evidence of multi-trait colocalization between the index protein, intermediate phenotypes, and the index cancer endpoint (Supplementary data 5), which may serve to elucidate aetiological pathways to cancer risk. The gene discussed is ASIP; the disease is cancer.