We observed only limited evidence for the association of pLOF variants in cognate genes for cancer risk proteins with other traits in the UK Biobank using Genebass or the AstraZeneca PheWAS Portal, none of which were cancer endpoints (LAYN, PTGR1, FGFR3, VARS1, PTPN9), none of which were cancer endpoints. The gene discussed is VARS1; the disease is cancer.