PDXK and hypertensive disorder: However, lowering PDXK was also associated with higher systolic [Beta: 0.72, 95% CI: 0.49 to 0.95; PP4: 0.92] and diastolic blood pressure (mmHg) [Beta: 0.51, 95% CI: 0.38 to 0.64; PP4: 0.96], a higher risk of having hypertension [OR: 1.12, 95% CI: 1.07 to 1.15; PP4: 0.90].