Among others, it has been shown that Rho signaling is downstream of FGFR1-induced radioresistance in GBM cells79,80 and this is consistent with the pronounced Rho GTPase cycle activation predicted by the Reactome of the common phosphorylated proteins in BV-CM-treated GBM cells (Supplementary Fig. 15B). The gene discussed is FGFR1; the disease is glioblastoma.