CHEK2 and glioblastoma: The results of the kinase enrichment analysis of the upregulated proteins in both GBM cell lines at 6 h or 72 h following treatment with BV-CM indicate the common activation of the DDR machinery, particularly the kinases ATM, DNA-PK (also known as PRKDC), and CHEK2 (Fig. 8A), which is in line with the activation detected in CL3/NesHI cells (Fig. 4H).