Among the 557 proteins with increased phosphorylation in BV-CM GBM cells, SMARCs, HDAC2/4, AKT1, YAP1, NES, VIM, TOP2A/B, CHD4, ATRX, TP53 and TP53BP1 popped up as interesting hits (Fig. 8C, Supplementary Fig. 14C, Supplementary Data File 5). The gene discussed is CHD4; the disease is glioblastoma.