CX3CR1 and Hepatic fibrosis: These S100A proteins, in turn, amplify TLR-mediated signaling and activate hepatic stellate cells, ultimately promoting liver fibrosis.5 Finally, the authors demonstrated that Cx3cr1+Ccr2+MyD88+ Mo-macs produce S100A proteins, transcriptionally promoted by NF-κB signaling downstream of CX3CR1.