AKT1 and osteosarcoma: Emetine has been shown to modulate multiple intracellular signaling pathways, inhibiting the Wnt/β-catenin, PI3K/AKT and Hippo/YAP signaling pathways in gastric cancer [16]; inhibiting Hedgehog signaling in an in-silico study [29]; and activating p38 and inhibiting ERK, JNK, and β-catenin signaling in osteosarcoma cells [15].