The mutational landscape of MM is highly complex, and includes primary translocations enhancing the expression of CCND1, FGFR3/MMSET, and MAF paralogues [t(11;14), t(4;14), t(14;16) and t(14;20), respectively], hyperdiploidy of odd chromosomes, copy number variations (CNV), secondary translocations, as well as single nucleotide variants (SNV) and short insertions/deletions (indels) [6]. This evidence concerns the gene FGFR3 and Miyoshi myopathy.