A study showed that knockdown of RIPK3 significantly alleviated hepatic steatosis, liver injury, oxidative damage, fibrosis, and inflammation in mice with methionine-deficient and choline-deficient diet-induced NASH, whereas it aggravated hepatic steatosis and inflammation in mice fed a high-fat diet (HFD) [78]. This evidence concerns the gene RIPK3 and fatty liver disease.