Serum levels of antibodies against PRMT5, measured as absorbance signals at 405 nm by ELISA, were significantly higher in patients with SSc, compared with HC or the patients with SLE and SjS (SSc vs HC p<0.001; SSc vs SLE p<0.001; SSc vs SjS p=0.003) (figure 3A). The gene discussed is PRMT5; the disease is systemic lupus erythematosus.