In addition, systemic analysis using GO and Reactome databases demonstrated several terms relevant to SSc in the lungs of PRMT5/CFA-immunised mice, including ‘response to IL-13’, ‘wound healing involved in inflammatory response’, ‘response to hypoxia’, ‘antigen receptor-mediated signalling pathway’, ‘classical antibody-mediated complement activation’ and ‘immunoregulatory interactions between a lymphoid and a non-lymphoid cell’ (online supplemental figure S11G,H). The gene discussed is PRMT5; the disease is systemic sclerosis.