The gene sets encompass numerous genes previously implicated in the pathogenesis of SSc, such as Acta2, Col1a1, Col3a1, Smad3, Ctgf, Msr1, Cd4, Cd8a and Cd68, supporting the potential of anti-PRMT5 in induction of SSc-like skin changes. This evidence concerns the gene SMAD3 and Abnormality of the skin.