Therefore, the role of autoimmunity of anti-PRMT5 was then assessed in an immunisation model, which has been extensively used for model establishment, such as experimental allergic encephalomyelitis,34 collagen-induced arthritis,35 glucose-6-phosphate isomerase-induced arthritis36 as well as Topo I immunised SSc.23 Indeed, induction of tissue fibrosis and immune infiltration in mice immunised by recombinant protein PRMT5 illustrated that the antibody response to PRMT5 was likely to result in SSc-like manifestations. Here, PRMT5 is linked to systemic sclerosis.