IL6 and temporal arteritis: For instance, studies have shown that macrophages and T-cells are important players in cranial-GCA and LV-GCA as well as PMR, yet research to date shows that B-cells appear to predilect the aorta.122 123 Similarly, IL-6 signatures have been linked to all three, however more clinical relapses are characteristically seen in LV-GCA patients.32 In addition, the disconnect between systemic and tissue inflammation further complicates the paradigm.