The findings revealed that ICI increased the risk of CIP compared to chemotherapy, irrespective of PD-L1 expression levels (OR = 4.32, 95% CI: 2.22–8.41, p < 0.0001; OR = 3.60, 95% CI: 1.56–8.28, p = 0.003). This evidence concerns the gene CD274 and hereditary sensory and autonomic neuropathy.