Subgroup analysis further indicated that the group with PD-L1 > 50% had a higher risk of developing CIP of all grades and grades 3–5 (OR = 13.44, 95% CI: 5.09–35.48, p < 0.00001; OR = 9.91, 95% CI: 1.73–56.58, p = 0.01) (Fig 7). Here, CD274 is linked to hereditary sensory and autonomic neuropathy.