For example, diabetes induces the production of TNF-α and IL-1β which are known as the major proinflammatory cytokines that result in diabetes-associated cognitive decline [2], and TNF-α can be generated by hyperglycemia and enhance the transcription factor NF-κB via TNF-α receptor activation on the surface of neurons and glia cells [41]. This evidence concerns the gene NFKB1 and Hyperglycemia.