In addition, the induction of cytoplasmic RUNX3 retention under hypoxic culture condition in gastric cancer cells occurs via the upregulation of histone deacetylase (HDAC) and histone methyltransferase (HMT), euchromatic histone-lysine N-methyltransferase 2 (EHMT2/G9a) [18]. This evidence concerns the gene RUNX3 and gastric cancer.