The univariate Cox analysis for survival in patients with HF and sarcopenia showed that age ≥ 85 years (hazard ratio [HR] 2.316, 95% confidence interval [CI]: 1.270–4.227, p = 0.006), higher NYHA functional class (HR 1.543 per class, 95% CI: 1.061–2.244, p = 0.023), reduced LVEF (HR 2.469 per class, 95% CI: 1.383–4.405, p = 0.002), and log BNP level ≥ 2.5 (HR 3.454 per class, 95% CI: 1.789–6.668, p < 0.001) had significant predictive values. This evidence concerns the gene NPPB and sarcopenia.