NFKB1 and chronic kidney disease: Additionally, 5-MTP can inhibit the proliferation and migration of tumor cells by hampering the p38-MAPK/NF-kB pathway, stenosis caused by the vascular injury-induced proliferation of endothelial and smooth muscle cells, chronic kidney disease (CKD) progression as well as renal and liver fibrosis as seen in various studies on tumorigenesis [8], inflammation inhibition [9], peripheral artery disease [10], CKD [11], and liver fibrosis [12].