NPPB and type 2 diabetes mellitus: Subgroup multivariable COX regression analysis (Fig. 4 A ~ F) showed that the predictive value of 5-MTP for 1-year MACE was more significant in patients ≤ 65 years (HR = 0.299, 95%Cl 0.124–0.718, p = 0.007), males (HR = 0.298, 95%Cl 0.125–0.711, p = 0.006) and those with high NT-proBNP (HR = 0.299, 95%Cl 0.139–0.645, p = 0.002), T2DM (HR = 0.172, 95%Cl 0.059–0.502, p = 0.001), STEMI (HR = 0.235, 95%Cl 0.100–0.551, p = 0.001), and baseline HFpEF (HR = 0.115, 95%Cl 0.017–0.771, p = 0.026) characteristics.