Xiaofei Qiu et al. showed that inhibiting NLRP3 inflammasome overactivation can protect dopaminergic neurons in mouse PD models [15], while Shuxuan Huang et al. indicated that NLRP3, rather than NLRP1 and NLRP2, may represent a key inflammasome that promotes the pathogenesis of MPTP-induced PD [16]. This evidence concerns the gene NLRP1 and Parkinson disease.