Furthermore, knockout of the RNA binding protein muscleblind-like 1 (MBNL1) can promote cardiomyocyte proliferation in mouse heart after MI [14], and osteopontin (OPN) was found to enable cardiomyocyte re-entry into cell cycle in mouse heart, but also to stimulate other cells to improve scar formation and left ventricular remodeling [152]. The gene discussed is SPP1; the disease is myocardial infarction.