In contrast, mitochondrial transmembrane protein 11 (TMEM11)-mediated N7-methylguanosine (m7G) methylation negatively regulates cardiomyocyte proliferation and cardiac function in mouse in vivo after MI via targeting TMEM11-methyltransferase 1, tRNA methylguanosine (METTL1)-activating transcription factor 5 (ATF5)-inhibitor of CDK, cyclin A1 interacting protein 1 (INCA1) axis[34]. Here, TMEM11 is linked to myocardial infarction.