KCNJ2 and Arrhythmia: Dysfunctional KIR2.1 channels will disrupt the hearts normal electrical activity, leading to irregular heart rhythms and potentially life-threatening arrhythmias (Crotti et al. 2020; Reilly and Eckhardt 2021; Van Der Schoor et al. 2020; Zangerl-Plessl et al. 2019).