Fluid absorption in the intestine is critically dependent on the function of apical transporters, such as sodium-dependent glucose cotransporter 1 (SGLT1/SLC5A1), sodium-proton exchanger 3 (NHE3/SLC9A3), down-regulated in adenocarcinoma (DRA/SLC26A3), solute carrier organic anion transporter 2A1 (SLCO2A1), and the apical sodium/bile acid transporter (ASBT/SLC10A2). This evidence concerns the gene SLC10A2 and adenocarcinoma.