Several case reports suggest that loss-of-function mutations in these trafficking-associated proteins cause a variant of the phenotype found in classical MVID due to MYO5B (Alsaleem et al., 2017; Duclaux-Loras et al., 2022; Hackmann et al., 2013; Stepensky et al., 2013; Vogel et al., 2017; Wiegerinck et al., 2014). Here, MYO5B is linked to microvillus inclusion disease.