In this study, we investigated cytokine production in response to multiple myeloma (MM) cells expressing BCMA using KMS-12-PE (BCMAlow) or NCI-H929 (BCMAhigh) cells co-cultured with UTD, anti-BCMA-CAR2, or anti-BCMA-CAR3 T cells at an effector to target (E:T) ratio of 5:1. Here, CA3 is linked to plasma cell myeloma.