RANKL stimulation in multiple myeloma-derived osteoclasts induced elevated co-translocation of the cytosolic osteoclast-inducing essential transcription factors of NF-κB (p65 subunit) and NFATc1, and SELENOW into the nucleus as compared to that in the control cells (Fig. 2c). The gene discussed is NFKB1; the disease is plasma cell myeloma.