Our analysis revealed that in regulating signal transmission from tumor cells to smooth muscle cells (SMCs) - as shown in Figure 5G - the signal intensity of VEGFA-VEGFR1, MDK-SDC1/SDC4, MDK-LRP1, MDK-(ITGA4+ITGB1), GNR-SORT1, and GDF15-TGFBR2 exhibits higher levels in LM, whereas LGALS9-CD44/CD45 predominates in pCRC. This evidence concerns the gene GDF15 and neoplasm.