Concerning the regulation of signal transmission from SMCs to tumor cells, as depicted in Figure 5H, the signal intensity of TNFSF14-TNFRSF14/LTBR, TNFSF12-TNFRSF12A, and ANGPTL4-SDC1/SDC4 demonstrates higher levels in LM, whereas TNF-TNFRSF1A and RETN-CAP1 are predominant in pCRC. This evidence concerns the gene SDC4 and neoplasm.