In summary, our postulation posits that SMCs and TEXs leverage the interaction between ligand-receptor pairs, such as ANGPTL4-SDC1/SDC4 and MIF-(CD74+CD44), in cell communication to activate downstream transcription factors, thereby participating in the regulation of the EMT program within the context of CRC and precipitating the emergence of LM. This evidence concerns the gene CD44 and colorectal carcinoma.