We also observed a significant negative correlation between the expression levels of miR‐429 and CRKL in CML patients, to further confirm the negative correlation between miR‐429 and CRKL, we detected the effect of miR‐429 deregulation on the expression levels of CRKL in K562 cells, miR‐429 overexpression decreased endogenous CRKL expression level (Figure 5B). The gene discussed is CRKL; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.