miR‐429‐CRKL axis regulated HCC and ccRCC malignant progression through Raf/MEK/ERK and SOS1/MEK/ERK/MMP2/MMP9 pathways,40, 41 previously, we also found that CRKL regulated proliferation, migration and invasion of K562 cells through PI3K‐Akt/mTOR and p130CAS/CRKL/Dock180/RAC1 pathways (unpublished). This evidence concerns the gene RAC1 and hepatocellular carcinoma.