UHRF1 was able to prevent apoptosis in both gallbladder cancer and colorectal cancer cells,14, 15 promote cell cycle in GBC cells,14 promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression,16 inducing epithelial‐mesenchymal transition by upregulating CXCR4 in cancer cells,17 and promoting aerobic glycolysis.19 This evidence concerns the gene SEMA3E and gallbladder cancer.