It has also been reported that CEnCs from patients with Fuchs endothelial corneal dystrophy (FECD), which is a leading cause of CEnC dysfunction in the world [11], have predominantly higher expression of p16 and p21 compared to healthy subjects [12, 13], suggesting there is a link between FECD and cellular senescence [14]. Here, CDKN2A is linked to Fuchs endothelial corneal dystrophy.