Of the 30 samples with positive ANA or infectious serology, 16 were negative for both IgM and IgG, 5 IgM-/IgG+ (4 ANA, 1 EBV), 7 IgM+/IgG- (2 EBV, 5 Syphilis), and 2 IgM+/IgG+ (2 EBV). The gene discussed is CD40LG; the disease is syphilis.