Accordingly, WDR5 is an auspicious target for inhibition in a range of malignancies including MLL-rearranged (MLLr) leukemias (Cao et al., 2014; Aho et al., 2019a), MYC-driven cancers (Aho et al., 2019b), C/EBPα-mutant leukemias (Grebien et al., 2015), p53 gain-of-function cancers (Zhu et al., 2015), neuroblastomas (Bryan et al., 2020), rhabdoid tumors (Florian et al., 2022), and metastatic breast cancers (Cai et al., 2022). Here, MYC is linked to leukemia.