RNPC3 and glioblastoma: 83), tRNA and yRNAs (Ref. 84), and have an RNA signature readily distinguishable from EVs. The mRNA fraction of extracellular RNPs derived from glioblastoma cells was shown to be less than 5% of total RNP RNA (Ref. 60), but an improvement in RNP purification methods are needed to further solidify the composition of RNPs (Ref. 84). Finally, virtosomes (Ref. 63) and SMAPs (supramolecular attack particles) (Ref. 85) are both EPs that potentially, and a priori contain mRNA but warrant further investigation.