Experimental analyses confirmed AQB's robust inhibitory actions on HOTAIR, and the consequent upregulation of tumour suppressor gene, antigen-presenting cell (APC) regulator of WNT signalling pathway 2 and repression of Wnt/β-catenin cascade in primary patient-derived glioblastoma cells, N5 and N33. This evidence concerns the gene HOTAIR and glioblastoma.