HOTAIR and spinocerebellar ataxia type 1: 20). It should be noted here that ataxin-1 is a crucial regulator of developmental pathways in the brain and its post-translational modifications and mutations in its gene are thought to be associated with CNS dysfunctions such as spinocerebellar ataxia type 1 (Ref. 21). Similarly, interactions of HOTAIR with Mex3b and the consequent alterations in functions of suppressor of mothers against decapentaplegic family member 4 and nucleoside diphosphate linked moiety X-type motif 3 (Ref. 22) may suggest potential participation of HOTAIR in multiple neurobiological processes.