Muscle‐specific UCP3 transgenic mice have improved glucose homeostasis under chow and high‐fat diet (HFD) conditions, as well as resistance to obesity‐induced diabetes.S36–S38 Moreover, increased levels of circulating lipids increase UCP3 expression.S39, S40 We demonstrate that Nr2f6 is downregulated when C2C12 cells are exposed to fatty acids and when there is an increase in β‐oxidation in mice. This evidence concerns the gene NR2F6 and obesity due to melanocortin 4 receptor deficiency.