IGF2BP1 is an RNA‐binding protein with important functions in organ development and proliferation of cancer cells and myoblasts.S8,S9,S10 ECRG4 is a secreted peptide regarded as a tumour suppressorS11 and is required for proper cardiomyocyte differentiation.S12 These phenotypes are consistent with the presented Nr2f6 knockdown models, and further studies should investigate the functional relationship between Nr2f6 and ECRG4. This evidence concerns the gene ECRG4 and neoplasm.