Nr2f6 expression showed a strong tendency (P = 0.056) towards an increase in gastrocnemius of elder mice (S5B), which displayed upregulated Myod1 and myogenin.S1,S2 Mining public datasets (Figure S5A), we found that Nr2f6 is increased in biopsies from hereditary spastic paraplegia (HSP)S3 and decreased in dermatomyositis (DM). Here, MYOG is linked to hereditary spastic paraplegia.