Ccnb1 ectopic expression increases cell proliferation rates and it is upregulated in several types of cancer.S56,S57,S58 The simultaneous effect of Nr2f6 modulation on cell cycle and differentiation markers might also be sustained indirectly by RB1, which is responsible for cell cycle arrest through the inhibition of the E2F family of transcription factors. The gene discussed is NR2F6; the disease is cancer.