NR2F6 and cancer: In cancer cells, Nr2f6 overexpression and knockdown can promote or inhibit cell proliferation, respectively.S21–S23 Doubling time experiments confirm that this effect is also conserved in C2C12 myoblasts, with an increase (4 h) in the average doubling time by Nr2f6 depletion and a decrease (3.5 h) by Nr2f6 overexpression (Figure 6C,E).