YY2 and colorectal carcinoma: To further explore the role of YY2 in regulating SAC activity and subsequently mitotic exit, we altered YY2 expression in HCT116 cells, a near‐diploid human CRC cell line with a mitotic time similar to that of normal cells and considered CIN‐negative cells (Figure S1C,D, Supporting Information).[27] As shown by time‐lapse microscopic images, YY2 overexpression delayed the mitosis, whereas YY2 knockout significantly accelerated it (Figure 1E,F, Videos S1–S4, Supporting Information).