Subsequently, our results also demonstrated that YY2 overexpression‐induced SAC hyperactivation, which triggers excessive CIN, significantly sensitizes CRC cells to oxaliplatin and paclitaxel, indicating a synergism between YY2/SAC hyperactivation‐induced excessive CIN and DNA damage‐inducing agents. Here, ADCY10 is linked to cervical squamous intraepithelial neoplasia.