DNA damage‐inducing agents such as oxaliplatin, taxol, and radiotherapy, which have been used clinically for treating tumors, can induce mitotic errors and CIN;[5, 10, 47, 65] while SAC activator, such as MK‐1775 and ZN‐c3, are in clinical trials and are considered as potential anti‐tumor drugs.[66] Meanwhile, increasing evidences suggest that a population of tumor cells remain viable after exposure to various anti‐tumor drugs. This evidence concerns the gene ADCY10 and neoplasm.