Obviously, while excessive CIN will eventually lead to cell death, the effect of YY2 alteration on intrinsic characteristics of the cells, such as their gene expression profiles in responses to DNA damage stress and apoptotic stimuli, also contribute greatly to their capacity in tolerating CIN stress, and subsequently, the threshold of CIN‐induced cell death. This evidence concerns the gene YY2 and cervical squamous intraepithelial neoplasia.