These results conform with previous studies showing that SAC activation could also induce CIN and furthermore, cell death.[16, 39] To further confirm the causal relation between YY2 overexpression‐induced SAC hyperactivation and CIN, we suppressed SAC activity in HCT116 cells overexpressing YY2. This evidence concerns the gene YY2 and cervical squamous intraepithelial neoplasia.