Moreover, while knocking out YY2 alone did not induce cell death and even benefits tumor cell proliferation, treatment with reversine, which could further weaken SAC activity as indicated by the shortened mitotic time (Figure S9C,D and Videos S10, Supporting Information), increased CIN as well as cell death in HCT116YY2KO cells (Figure S9E,F, Supporting Information). Here, YY2 is linked to neoplasm.