Given that YY2 overexpression induces excessive CIN, we examined its synergistic effect with oxaliplatin and paclitaxel, which are DNA damage‐inducing agents that can induce CIN.[5, 46, 47]YY2 overexpression significantly decreased the IC50 of oxaliplatin; in contrast, YY2 knockout robustly increased it (Figure 7A,B). This evidence concerns the gene YY2 and cervical squamous intraepithelial neoplasia.