Furthermore, the artificial cyclization and anti‐PD‐L1 aptamer (PA1) with the delivery function that we have reported were introduced to increase stability and efficient delivery.[20] The circular PA1‐ProMyc (circPA1‐ProMyc) potently suppresses tumorigenesis in xenografted tumor mice, providing a potential degrader for drug discovery targeting c‐Myc. This evidence concerns the gene CD274 and neoplasm.